Publication details

Nanoparticle-Based Immunochemical Biosensors and Assays: Recent Advances and Challenges

Authors

FARKA Zdeněk JUŘÍK Tomáš KOVÁŘ David TRNKOVÁ Libuše SKLÁDAL Petr

Year of publication 2017
Type Article in Periodical
Magazine / Source Chemical Reviews
MU Faculty or unit

Central European Institute of Technology

Citation
web http://pubs.acs.org/doi/abs/10.1021/acs.chemrev.7b00037
Doi http://dx.doi.org/10.1021/acs.chemrev.7b00037
Field Analytic chemistry
Keywords Immunosensor; Immunoassay; Nanoparticle; Antibody
Description We review the progress achieved during the recent five years in immunochemical biosensors (immunosensors) combined with nanoparticles for enhanced sensitivity. The initial part introduces antibodies as classic recognition elements. The optical sensing part describes fluorescent, luminescent, and surface plasmon resonance systems. Amperometry, voltammetry, and impedance spectroscopy represent electrochemical transducer methods; electrochemiluminescence with photoelectric conversion constitutes a widely utilized combined method. The transducing options function together with suitable nanoparticles: metallic and metal oxides, including magnetic ones, carbon-based nanotubes, graphene variants, luminescent carbon dots, nanocrystals as quantum dots, and photon up-converting particles. These sources merged together provide extreme variability of existing nanoimmunosensing options. Finally, applications in clinical analysis (markers, tumor cells, and pharmaceuticals) and in the detection of pathogenic microorganisms, toxic agents, and pesticides in the environmental field and food products are summarized.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info