Publication details
Role specifické buněčné imunity v patogenezi roztroušené sklerózy se zaměřením na Th17 a Treg lymfocyty
| Title in English | The role of the cell-mediated immunity in the pathogenesis of multiple sclerosis with focus on Th17 and treg lymfocytes |
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| Authors | |
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská neurologie a neurochirurgie |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.14735/amcsnn2017173 |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | B lymphocytes; Multiple sclerosis; Regulatory T lymphocytes; T lymphocytes; Th17 lymphocytes |
| Description | Multiple sclerosis is a serious autoimmune disease of the central nervoussystem. It occurs with relatively high prevalence, especially in young people. It is essential to understand the pathogenesis of this disease in order to develop new treatments. All components of immunity are involved in this process but current research mainly focuses on lymphocyte populations. Previously, imbalance between subtypes of helper lymphocytes Th1 and Th2 was considered as the main cause of multiple sclerosis. Recently, the influence of other cell elements, such as B lymphocytes, cytotoxic T lymphocytes, wasshown. Moreover, new cell types, regulatory T lymphocytes and helper Th17 lymphocytes, have been discovered. The aim of this article is to describe the main roles of individuallymphocyte subtypes in multiple sclerosis pathogenesis, focusing first on regulatory T lymphocytes and helper Th17 lymphocytes. |