Publication details

Aerosol Health Effects from Molecular to Global Scales

Authors	SHIRAIWA Manabu UEDA Kayo POZZER Andrea LAMMEL Gerhard KAMPF Christopher J. FUSHIMI Akihiro ENAMI Shinichi ARANGIO Andrea M. FROHLICH-NOWOISKY Janine FUJITANI Yuji FURUYAMA Akiko LAKEY Pascale S. J. LELIEVELD Jos LUCAS Kurt MORINO Yu POSCHL Ulrich TAKAHARNA Satoshi TAKAMI Akinori TONG Haijie WEBER Bettina YOSHINO Ayako SATO Kei
Year of publication	2017
Type	Article in Periodical
Magazine / Source	ENVIRONMENTAL SCIENCE & TECHNOLOGY
MU Faculty or unit	Faculty of Science
Citation
web	https://pubs.acs.org/doi/10.1021/acs.est.7b04417
Doi	http://dx.doi.org/10.1021/acs.est.7b04417
Keywords	SECONDARY ORGANIC AEROSOL; FINE-PARTICULATE MATTER; LONG-TERM EXPOSURE; POLYCYCLIC AROMATIC-HYDROCARBONS
Description	Poor air quality is globally the largest environmental health risk. Epidemiological studies have uncovered clear relationships of gaseous pollutants and particulate matter (PM) with adverse health outcomes, including mortality by cardiovascular and respiratory diseases. Studies of health impacts by aerosols are highly multidisciplinary with a broad range of scales in space and time. We assess recent advances and future challenges regarding aerosol effects on health from molecular to global scales through epidemiological studies, field measurements, health-related properties of PM, and multiphase interactions of oxidants and PM upon respiratory deposition. Global modeling combined with epidemiological exposure response functions indicates that ambient air pollution causes more than four million premature deaths per year. Epidemiological studies usually refer to PM mass concentrations, but some health effects may relate to specific constituents such as bioaerosols, polycyclic aromatic compounds, and transition metals. Various analytical techniques and cellular and molecular assays are applied to assess the redox activity of PM and the formation of reactive oxygen species. Multiphase chemical interactions of lung antioxidants with atmospheric pollutants are crucial to the mechanistic and molecular understanding of oxidative stress upon respiratory deposition. The role of distinct PM components in health impacts and mortality needs to be clarified by integrated research on various spatiotemporal scales for better evaluation and mitigation of aerosol effects on public health in the Anthropocene.