Publication details

Metabolic activity of sulfate-reducing bacteria from rodents with colitis

Authors

KOVÁČ Jozef VÍTĚZOVÁ Monika KUSHKEVYCH Ivan

Year of publication 2018
Type Article in Periodical
Magazine / Source Open Medicine
MU Faculty or unit

Faculty of Science

Citation
Web https://www.degruyter.com/view/j/med.2018.13.issue-1/med-2018-0052/med-2018-0052.xml?format=INT
Doi http://dx.doi.org/10.1515/med-2018-0052
Keywords Sulfate-reducing bacteria; Desulfovibrio genera; Hydrogen sulfide; Ulcerative colitis
Description Sulfate-reducing bacteria (SRB) are anaerobic microorganisms, which use sulfate as an electron acceptor in the process of dissimilatory sulfate reduction. The final metabolic product of these anaerobic microorganisms is hydrogen sulfide, which is known as toxic and can lead to damage to epithelial cells of the large intestine at high concentrations. Different genera of SRB are detected in the large intestine of healthy human and animals, and with diseases like Crohn’s disease and ulcerative colitis. SRB isolated from rodents with ulcerative colitis have produced 1.14 (mice) and 1.03 (rats) times more sulfide ions than healthy rodents. The species of Desulfovibrio genus are the most widespread among all SRB in the intestine. The object of our research was to observe and compare the difference of production of sulfide and reduction of sulfate in intestinal SRB isolated from healthy rodents and rodents with ulcerative colitis.

You are running an old browser version. We recommend updating your browser to its latest version.

More info