Publication details
The human V delta 2(+) T-cell compartment comprises distinct innate-like V gamma 9(+) and adaptive V gamma 9(-) subsets
| Authors | |
|---|---|
| Year of publication | 2018 |
| Type | Article in Periodical |
| Magazine / Source | Nature Communications |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1038/s41467-018-04076-0 |
| Keywords | ANTIGEN RECEPTOR; FETAL-DEVELOPMENT; MOLECULAR-BASIS; B30.2 DOMAIN; MAIT CELLS; GAMMA; BLOOD; RESPONSES; CYTOMEGALOVIRUS; REPERTOIRE |
| Description | V delta 2(+) T cells form the predominant human gamma delta T-cell population in peripheral blood and mediate T-cell receptor (TCR)-dependent anti-microbial and anti-tumour immunity. Here we show that the V delta 2(+) compartment comprises both innate-like and adaptive subsets. V gamma 9(+) V delta 2(+) T cells display semi-invariant TCR repertoires, featuring public V gamma 9 TCR sequences equivalent in cord and adult blood. By contrast, we also identify a separate, V gamma 9(-) V delta 2(+) T-cell subset that typically has a CD27(hi)CCR7(+)CD28(+)IL-7R alpha(+) naive-like phenotype and a diverse TCR repertoire, however in response to viral infection, undergoes clonal expansion and differentiation to a CD27(lo)CD45RA(+)CX(3)CR1(+) granzymeA/B+ effector phenotype. Consistent with a function in solid tissue immunosurveillance, we detect human intrahepatic V gamma 9(-) V delta 2(+) T cells featuring dominant clonal expansions and an effector phenotype. These findings redefine human delta d T-cell subsets by delineating the V delta 2(+) T-cell compartment into innate-like (V gamma 9(+)) and adaptive (V gamma 9(-)) subsets, which have distinct functions in microbial immunosurveillance. |
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