Publication details
Refrakterní septický šok u dětí - definice ESPNIC
| Title in English | Refractory septic shock in children - ESPNIC definition |
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| Authors | |
| Year of publication | 2018 |
| MU Faculty or unit | |
| Citation | |
| Description | In 2016, the definition of sepsis in adult patients was revised and updated. The purpose of the new definition of Sepsis-3 was to help doctors identify patients in septic shock and allow their timely treatment based on the risk of mortality. The SOFA score has a crucial place in this definition, but this score is neither adapted nor validated for pediatric patients. The course of septic shock is influenced by the age and the patient's immune system, pathogen virulence, and haemodynamic response to circulatory failure. In pediatric septic patients, a PELOD score is used, but similar to a SOFA score, this scoring system does not affect treatment at the bedside. A certain subset of patients does not respond to standard resuscitation therapy and is often referred to as a "refractory septic shock". Effective circulation support with newer vasoactive substances or extracorporeal support (ECLS) has the potential to reverse the course of RSS. For the maximum effectiveness of these rescue procedures, a powerful tool is needed for early identification of RSS patients. The infection, systemic inflammation and sepsis section of ESPNIC has established a scoring system aimed at early identification of patients with refractory septic shock and a high mortality risk that can be used at any time during the care of a pediatric patient. This scoring system was subsequently validated in a multicenter international retrospective cohort study. |