Publication details

Simplified novel prognostic score for real-life older adults with multiple myelomaregistry-based analysis

Authors

RADOCHA J. HÁJEK Roman BROŽOVÁ Lucie POUR Luděk ŠPIČKA I. MINAŘÍK J. GREGORA E. JUNGOVÁ A. JELÍNEK T. HEINDORFER A. SÝKORA M. MAISNAR V.

Year of publication 2019
Type Article in Periodical
Magazine / Source Annals of hematology
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.1007/s00277-018-3568-2
Doi http://dx.doi.org/10.1007/s00277-018-3568-2
Keywords Multiple myeloma; Older adults; Prognostic factors
Description The main goal was to find a simple prognostic to evaluate overall survival of patients older than 65years of age with myeloma. Retrospective registry-based analysis from the Registry of Monoclonal Gammopathies was conducted. Patients over 65years with symptomatic myeloma were included. The four major parameters with impact on survival were identified: male gender, age>75, creatinine >152mol/L, and ECOG performance status 2-4. The patients were scored as good (0 points), intermediate good (1 point), intermediate poor (2 points), poor (3-4 points). Patients (1410 MM) were included. Median OS (months) was 65.7 (95% CI 49.8-81.7) for good, 51.0 (44.1-57.8) for intermediate good, 32.2 (26.2-38.2) for intermediate poor, and 18.9 (15.1-22.7) for poor. The differences in OS were statistically significant (p<0.0001). Good score was used as reference for hazard ratios, which for each other score were 1.43 (1.09-1.84) for intermediate good, 2.58 (2.00-3.33) for intermediate poor, and 3.88 (2.94-5.10) for poor. Time to progression showed medians (months) 20.5 (17.4-62.4) for good, 19.3 (17.0-21.7) for intermediate good, 19.6 (16.2-23.0) for intermediate poor, and 13.0 (10.8-15.2) for poor. The suggested scoring system provides readily available information about the prognosis of MM patients above 65years.

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