An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice

• Authors: EYER Luděk; NOUGAIREDE Antoine; UHLÍŘOVÁ Marie; DRIOUICH Jean-Sélim; ZOUHAROVÁ Darina; VALDÉS James J.; HAVIERNIK Jan; GOULD Ernest A.; DE CLERCQ Erik; DE LAMBALLERIE Xavier; RŮŽEK Daniel
• Year of publication: 2019
• Type: Article in Periodical
• Magazine / Source: JOURNAL OF VIROLOGY
• Web: https://jvi.asm.org/content/93/16/e00367-19.long
• Doi: http://dx.doi.org/10.1128/JVI.00367-19
• Keywords: BCX4430; attenuation; drug resistance; galidesivir; mutation; tick-borne encephalitis virus