Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness

• Authors: EYER Luděk; KONDO Hirofumi; ZOUHAROVÁ Darina; HIRANO Minato; VALDÉS James J.; MUTO Memi; KASTL Tomáš; KOBAYASHI Shintaro; HAVIERNIK Jan; IGARASHI Manabu; KARIWA Hiroaki Kariwa; VACULOVIČOVÁ Markéta; ČERNÝ Jiří; KIZEK René; KRÖGER Andrea; LIENENKLAUS Stefan; DEJMEK Milan; NENCKA Radim; PALUS Martin; SALÁT Jiří; DE CLERCQ Erik; YOSHII Kentaro; RŮŽEK Daniel
• Year of publication: 2017
• Type: Article in Periodical
• Magazine / Source: JOURNAL OF VIROLOGY
• Web: https://jvi.asm.org/content/91/21/e01028-17
• Doi: http://dx.doi.org/10.1128/JVI.01028-17
• Keywords: antiviral agentsantiviral therapyescape mutanttick-borne encephalitis virustick-borne pathogens