Publication details

Essential tremor-plus: a controversial new concept

Authors

LOUIS Elan D. BAREŠ Martin BENITO-LEON Julian FAHN Stanley FRUCHT Steven J. JANKOVIC Joseph ONDO William G. PAL Pramod K. TAN Eng-King

Year of publication 2020
Type Article in Periodical
Magazine / Source Lancet Neurology
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.1016/S1474-4422(19)30398-9
Doi http://dx.doi.org/10.1016/S1474-4422(19)30398-9
Keywords CONSENSUS STATEMENT; HEAD TREMOR; DISORDER; DYSTONIA; PREVALENCE; DEMENTIA; NETWORK; DECLINE; DISEASE
Description In addition to redefining essential tremor (ET), the 2018 consensus statement of the Movement Disorder Society on tremor coined a new term: essential tremor-plus (ET-plus). This term is uncertainly defined as tremor with the characteristics of ET, with additional neurological signs of uncertain clinical significance. If ET-plus had been defined on the basis of a difference in underlying pathology or an appreciable difference in prognosis, it would have a valid, scientific rationale, as does the term Parkinson-plus. However, there is no such evidence, so the basis for the term is questionable. In fact, ET-plus might only represent a state condition (ie, patients with ET might develop these additional clinical features when the disease is at a more advanced stage). We caution against coining new terms that are not supported by a firm scientific basis and encourage research into the creation of essential tremor subsets that are defined with respect to differences in underlying causes or pathophysiology.

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