Identifying urinary microRNAs for heart allograft rejection monitoring using small RNA sequencing - Pilot results

• Authors: NOVÁK Jan; MACHÁČKOVÁ Táňa; NOVÁKOVÁ Tereza; GODAVA Július; HUDE Petr; ŽAMPACHOVÁ Víta; OPPELT Jan; NĚMEC Petr; BEDÁŇOVÁ Helena; SLABÝ Ondřej; DOBROVOLNÁ Julie; KREJČÍ Jan; ŠPINAROVÁ Lenka
• Year of publication: 2019
• Type: Conference abstract
• MU Faculty or unit: Central European Institute of Technology
• Description: Heart failure (HF) represents one of the leading causes of death in the developed countries and heart transplantation (HT) is the only solution for patients with terminal refractory HF. Patients after HT are at risk of acute cellular rejection (ACR) potentially causing graft damage and failure. Diagnostics of ACR is based on histopathologic evaluation of endomyocardial biopsies (EMB) as no non-invasive biomarker has been found yet. microRNAs (miRNAs, miRs) are tiny non-coding RNA molecules involved in post-transcriptional regulation of gene expression. Extracellularly they are potentially involved in intercellular communication and because of their high stability they represent novel potential biomarkers.

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