Publication details
New 1 3 5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity (PDF) New 1,3,5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity. Available from: https://www.researchgate.net/publication/337285387_New_13
| Authors | |
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| Year of publication | 2019 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
| Citation | HAVRÁNKOVÁ, Eva, Nikola ČALKOVSKÁ, Tereza PADRTOVÁ, Jozef CSÖLLEI, Radka OPATŘILOVÁ and Pavel PAZDERA. New 1 3 5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity (PDF) New 1,3,5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity. Available from: https://www.researchgate.net/publication/337285387_New_135-tria zine_Derivatives_Incorporating_Aminobenzenesulfonamide_Aminoalc ohol_Piperazine_Chalcone_or_Stilbene_Structural_Motifs_and_Eval uation_of_Their_Antiox. In The 23rd International Electronic Conference on Synthetic Organic Chemistry. 2019. Available from: https://dx.doi.org/10.3390/ecsoc-23-06598. |
| Description | A series of 1,3,5-triazine derivatives, incorporating aminobenzenesulfonamide, aminoalcohol/phenol, piperazine, chalcone, or stilbene structural motifs, were evaluated as potential antioxidants. The compounds were prepared by using step by step nucleophilic substitution of chlorine atoms in starting 2,4,6-trichloro-1,3,5-triazine. Reactions were catalyzed by Cu(I)-supported on a weakly acidic resin. The radical scavenging activity was determined in terms of %inhibition activity and IC50, using the ABTS method. Trolox and ascorbic acid (ASA) were used as standards. In the lowest used concentration 1 × 10-4 M, the %inhibition activity at time 0 min was comparable with both standards at least for 10 compounds. After 60 min compounds 1, 2, 9 and 25 showed nearly twice %inhibition (73.44–87.09%) in comparison with standards (Trolox = 41.49%; ASA = 31.07%). Values of IC50 correlated with %inhibition activity. For compounds 1, 2, 9 and 25 values of IC50 in time 60 min (17.16–27.78 µM) were 5 times lower than IC50 of both standards (Trolox = 178.33 µM; ASA = 147.47 µM). Based on these results, the presented 1,3,5-triazine derivatives and their analogs have a high potential in the treatment of illnesses caused or related to oxidative stress. |