Publication details
Effects of trichothecene mycotoxin T-2 toxin on haematological and immunological parameters of rainbow trout (Oncorhynchus mykiss)
| Authors | |
|---|---|
| Year of publication | 2020 |
| Type | Article in Periodical |
| Magazine / Source | Mycotoxin Research |
| MU Faculty or unit | |
| Citation | |
| web | https://doi.org/10.1007/s12550-020-00396-7 |
| Doi | https://doi.org/10.1007/s12550-020-00396-7 |
| Keywords | Fusarium; Fungi; Immunoglobulins; Erythropoiesis; Deoxynivalenol |
| Description | The aim of this study was to assess the effects of T-2 toxin–contaminated feed (at concentrations of 1.0 and 1.8 mg/kg) on the rainbow trout immune system by studying non-specific cellular and humoral immune responses and its effect on red and white blood cells. Consumption of T-2 toxin at both concentrations resulted in significantly increased erythrocyte counts and a decrease in mean corpuscular volume.While a significant decrease in mean corpuscular haemoglobin was observed at both experimental concentrations, the decrease in plasma haemoglobin was only significant at the higher T-2 toxin concentration. Higher T-2 toxin concentrations resulted in a significant increase in leukocyte and lymphocyte count, while absolute phagocyte count and counts of less mature neutrophil granulocyte forms remained unchanged at both concentrations. Non-specific humoral immunity (bactericidal activity measured as complement activation) decreased significantly in both experimental groups when compared with the control. The results of this study show that T-2 toxin in feed at a concentration range of 1.0–1.8 mg/kg influences the immunological defence mechanisms of rainbow trout. |