Publication details

Možnosti léčby farmakorezistentní schizofrenie v běžné klinické praxi

Title in English Treatment possibilities of pharmaco-resistant schizofrenie in common clinical practice
Authors

ČEŠKOVÁ Eva HÝŽA Martin

Year of publication 2020
Type Article in Periodical
Magazine / Source Psychiatrie pro praxi
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.solen.cz/artkey/psy-202002-0004_moznosti_lecby_farmakorezistentni_schizofrenie_v_bezne_klinicke_praxi.php?back=%2Fsearch.php%3Fquery%3Dfarmakoterapie%252520v%252520t%2525C3%252520%2525C2%252520hotenstv%2525C4%252520%2525C2%2525AD%26sfrom%3D11
Keywords pharmaco-resistant schizophrenia; clozapine; augmentation; combination of antipsychotics
Description The paper is focused on available therapeutic approaches to schizophrenia in common clinical practice. The literature and clinical experience stress the exclusion of pseudoresistance, caused mainly by nonadherence. The gold standard is clozapine. Further possibilities include augmentation and combination of antipsychotics; however, for these strategies there is not enough evidence and results are inconsistent. Augmentation is aimed mostly on persistent and dominant symptoms (depressive and negative symptoms, cognitive deficit). The most frequently used combination is combination of clozapine with an antipsychotic with complementary pharmacological profile.

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