Publication details
Transplantace jater jako potenciální kurativní metoda těžké hemofilie A: popis případu a literární přehled
| Title in English | Liver transplantation as potential curative method in severe hemophilia A: case report and literature review |
|---|---|
| Authors | |
| Year of publication | 2020 |
| Type | Article in Periodical |
| Magazine / Source | Vnitřní lékařství |
| MU Faculty or unit | |
| Citation | |
| web | https://casopisvnitrnilekarstvi.cz/artkey/vnl-202005-0016_liver-transplantation-as-potential-curative-method-in-severe-hemophilia-a-case-report-and-literature-review.php |
| Keywords | hemophilia A; chronic viral hepatitis C; liver transplantation |
| Description | The authors present clinical case of orthotopic liver transplantation for cirhosis due to chronic viral hepatitis C in a subject with severe hemophilia A. Preoperatively performed pharmacokinetic study with recombinant F VIII confirmed satisfactory in vivo recovery of 2.1 %. A bolus application of 52 units F VIII/kg body weight with target F VIII activity over 100.0 % was administred shortly before the transplantation started. Totally, 30 000 units of recombinant F VIII, 3 thrombocyte concentrates, 2 erythrocyte concentrates, 5 units of virally inactivated plasma, 1 unit of fresh frozen plasma and 3 500 antithrombin units were used. There were no perioperative or postoperative bleeding complications, F VIII substitution was stopped on postoperative day 3. The patient was discharged on twentieth postoperative day. |