Publication details

Transplantace jater jako potenciální kurativní metoda těžké hemofilie A: popis případu a literární přehled

Title in English Liver transplantation as potential curative method in severe hemophilia A: case report and literature review
Authors

POLÁK Pavel SMEJKAL Petr ROMANOVÁ Gabriela ZAVŘELOVÁ Jiřina HRDLIČKOVÁ Radomíra BLAHUTOVÁ Šárka HUSOVÁ Libuše ZVAROVÁ Marta PENKA Miroslav

Year of publication 2020
Type Article in Periodical
Magazine / Source Vnitřní lékařství
MU Faculty or unit

Faculty of Medicine

Citation
Web https://casopisvnitrnilekarstvi.cz/artkey/vnl-202005-0016_liver-transplantation-as-potential-curative-method-in-severe-hemophilia-a-case-report-and-literature-review.php
Keywords hemophilia A; chronic viral hepatitis C; liver transplantation
Description The authors present clinical case of orthotopic liver transplantation for cirhosis due to chronic viral hepatitis C in a subject with severe hemophilia A. Preoperatively performed pharmacokinetic study with recombinant F VIII confirmed satisfactory in vivo recovery of 2.1 %. A bolus application of 52 units F VIII/kg body weight with target F VIII activity over 100.0 % was administred shortly before the transplantation started. Totally, 30 000 units of recombinant F VIII, 3 thrombocyte concentrates, 2 erythrocyte concentrates, 5 units of virally inactivated plasma, 1 unit of fresh frozen plasma and 3 500 antithrombin units were used. There were no perioperative or postoperative bleeding complications, F VIII substitution was stopped on postoperative day 3. The patient was discharged on twentieth postoperative day.

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