Publication details

Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers

Authors

KINCL Vladimír PANOVSKÝ Roman PEŠL Martin MÁCHAL Jan JUŘÍKOVÁ Lenka HABERLOVÁ Jana MASÁROVÁ Lucia

Year of publication 2020
Type Article in Periodical
Magazine / Source Scientific Reports
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.nature.com/articles/s41598-020-77882-6.pdf
Doi http://dx.doi.org/10.1038/s41598-020-77882-6
Keywords Duchenne dystrophy; subclinical cardiac function impairment
Description To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p<0.001, 0.08 vs. 0.09 m/s, p<0.01 and 0.13 vs. 0.14 m/s, p=0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p=0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers.
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