Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease

• Authors: DI BARTOLOMEO Martina; ŠTARK Tibor; ORIANA MARIA Maurel; IANNOTTI Fabio Arturo; KUCHAR Martin; RUDÁ Jana; PISCITELLI Fabiana; LAUDANI Samuele; PEKAŘÍK Vladimír; SALOMONE Salvatore; AROSIO Beatrice; MECHOULAM Raphael; MACCARRONE Mauro; DRAGO Filippo; WOTJAK Carsten; DI MARZO Vincenzo; VISMARA Matteo; DELL'OSSO Bernardo; D'ADDARIO Claudio; MICALE Vincenzo
• Year of publication: 2021
• Type: Article in Periodical
• Magazine / Source: PHARMACOLOGICAL RESEARCH
• MU Faculty or unit: Faculty of Medicine
• Web: https://www.sciencedirect.com/science/article/pii/S1043661820316650?via%3Dihub
• Doi: http://dx.doi.org/10.1016/j.phrs.2020.105357
• Keywords: Schizophrenia; THC; Cannabinoid CB1 receptor; Dopamine D2 Receptor; Cannabidiol; DNA methylation; Epigenetics
• Description: Reported data add further evidence to the dopamine-cannabinoid interaction in terms of DRD2 and CNR1 dysregulation which could be implicated in the pathogenesis of schizophrenia spectrum disorders, suggesting that cannabidiol treatment may normalize pTHC-induced psychopathology by modulating the altered dopaminergic activity.

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