Publication details
Typy a příprava lipozomálních přípravků pro plicní podání
| Title in English | Types and Preparation of Liposomal Formulations for Pulmonary Administration |
|---|---|
| Authors | |
| Year of publication | 2020 |
| Type | Article in Periodical |
| Magazine / Source | CHEMICKÉ LISTY |
| MU Faculty or unit | |
| Citation | |
| web | http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3599 |
| Keywords | liposomes; lung application; spray drying; lyophylization; dry powder formulations; protectants |
| Description | The use of liposomes as carriers for different types of drugs in formulations to be administered to the lungs brings a number of advantages, including the possibility of controlled release, prolongation of retention at the site of action or reduced systemic exposure. However, the main disadvantage of liposomal suspensions is their physical and chemical instability. Therefore, they are preferably converted to dry powders by several drying technologies. In doing so, it is necessary to include specific excipients in the formulation, in particular protectants (saccharides), protecting liposomes from changes during these processes. |