Urine immunofixation negativity is not necessary for complete response in intact immunoglobulin multiple myeloma: Retrospective real-world confirmation

• Authors: RADOCHA Jakub; JELINEK Tomas; POUR Luděk; SPICKA Ivan; MINARIK Jiri; POPKOVA Tereza; JUNGOVA Alexandra; PAVLICEK Petr; BROŽOVÁ Lucie; ŠTORK Martin; SEDLAK Frantisek; KRHOVSKA Petra; MAISNAR Vladimir; HEINDORFER Adriana; SYKORA Michal; WROBEL Marek; MIKULA Peter; KESSLER Petr; ULLRYCHOVA Jana; HAJEK Roman
• Year of publication: 2021
• Type: Article in Periodical
• Magazine / Source: International Journal of Laboratory Hematology
• MU Faculty or unit: Faculty of Medicine
• Web: https://onlinelibrary.wiley.com/doi/10.1111/ijlh.13460
• Doi: http://dx.doi.org/10.1111/ijlh.13460
• Keywords: Urine immunofixation negativity; intact immunoglobulin multiple myeloma
• Description: The definition of complete disease response (CR) in multiple myeloma (MM) continues to be reevaluated. The last widely accepted model of response assessment was proposed by the International Myeloma Working Group (IMWG) in 2016.1 Urine immunofixation (uIFE), one of the CR parameters, is being frequently omitted from CR evaluation in routine clinical practice. Patients with missing uIFE are then reported as having very good partial response (VGPR).2 It has been recently suggested in retrospective analysis by Lahuerta et al3 that patients with intact immunoglobulin myeloma (IIMM) who lack uIFE examination present with the very same prognosis as the patients with negative uIFE and therefore uIFE might not be necessary for CR definition in such patients.