Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: an international population-based study

• Authors: CARDOSO R.; GUO F.; HEISSER T.; HACKL M.; IHLE P.; DE SCHUTTER H.; VAN DAMME N.; VALERIANOVA Z.; ATANASOV T.; MÁJEK Ondřej; MUŽÍK Jan; NILBERT M. C.; TYBJERG A. J.; INNOS K.; MAGI M.; MALILA N.; BOUVIER A. M.; BOUVIER V.; LAUNOY G.; WORONOFF A. S.; CARIOU M.; ROBASZKIEWICZ M.; DELAFOSSE P.; PONCET F.; KATALINIC A.; WALSH P. M.; SENORE C.; ROSSO S.; VINCERZEVSKIENE I.; LEMMENS V. E. P. P.; ELFERINK M. A. G.; JOHANNESEN T. B.; KORNER H.; PFEFFER F.; BENTO M. J.; RODRIGUES J.; DA COSTA F. A.; MIRANDA A.; ZADNIK V.; ZAGAR T.; MARQUES A. L. D.; MARCOS-GRAGERA R.; PUIGDEMONT M.; GALCERAN J.; CARULLA M.; CHIRLAQUE M. D.; BALLESTA M.; SUNDQUIST K.; SUNDQUIST J.; WEBER M.; JORDAN A.; HERRMANN C.; MOUSAVI M.; RYZHOV A.; HOFFMEISTER M.; BRENNER H.
• Year of publication: 2021
• Type: Article in Periodical
• Magazine / Source: Lancet Oncology
• MU Faculty or unit: Faculty of Medicine
• web: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(21)00199-6/fulltext
• Doi: http://dx.doi.org/10.1016/S1470-2045(21)00199-6
• Keywords: colorectal cancer; incidence; mortality; stage distribution; Europe
• Description: Findings In countries with long-standing programmes of screening colonoscopy and faecal tests (ie, Austria, the Czech Republic, and Germany), colorectal cancer incidence decreased substantially over time, with AAPCs ranging from -2 center dot 5% (95% CI -2 center dot 8 to -2 center dot 2) to -1 center dot 6% (-2 center dot 0 to -1 center dot 2) in men and from -2 center dot 4% (-2 center dot 7 to -2 center dot 1) to -1 center dot 3% (-1 center dot 7 to -0 center dot 9) in women. In countries where screening programmes were implemented during the study period, age-standardised colorectal cancer incidence either remained stable or increased up to the year screening was implemented. AAPCs for these countries ranged from -0 center dot 2% (95% CI -1 center dot 4 to 1 center dot 0) to 1 center dot 5% (1 center dot 1 to 1 center dot 8) in men and from -0 center dot 5% (-1 center dot 7 to 0 center dot 6) to 1 center dot 2% (0 center dot 8 to 1 center dot 5) in women. Where high screening coverage and uptake were rapidly achieved (ie, Denmark, the Netherlands, and Slovenia), age-standardised incidence rates initially increased but then subsequently decreased. Conversely, colorectal cancer incidence increased in most countries where no large-scale screening programmes were available (eg, Bulgaria, Estonia, Norway, and Ukraine), with AAPCs ranging from 0 center dot 3% (95% CI 0 center dot 1 to 0 center dot 5) to 1 center dot 9% (1 center dot 2 to 2 center dot 6) in men and from 0 center dot 6% (0 center dot 4 to 0 center dot 8) to 1 center dot 1% (0 center dot 8 to 1 center dot 4) in women. The largest decreases in colorectal cancer mortality were seen in countries with long-standing screening programmes.