Publication details
NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor
| Authors | |
|---|---|
| Year of publication | 2021 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
| Citation | |
| Description | Nicotinic acetylcholine receptor (nAChR) is an ancient allosteric membrane protein mediating synaptic transmission. These prototypic pentameric ligand-gated ion channels are expressed in many tissues & species, being involved in cognition, metabolism, neuromuscular transmission, and many pathologies (myasthenia gravis, Parkinson & Alzheimer diseases, addictions). Since its isolation in 1970, studies produced >5000 publications with huge amounts of structural-functional data. However, cumulative residue-level knowledge on nAChRs is not systematically accessible. Scatteredness of literature data, aliases, various receptor types & residue numberings make it harder to summarize current knowledge and apply it efficiently to promote further discoveries. There is no single resource providing access to & visualization of such information. NACHRDB fills this gap, delivering relevant structural-functional data together with computational predictions of allosterically important residues, and facilitating its interpretation via interactive 3D visualization & sequence alignment. It can help to study allosteric regulation, reveal gaps in current knowledge, and guide further studies in the field. |