Publication details
Metastatic intracranial spread of adenocarcinoma mimicking Creutzfeldt-Jakob disease in two cases
| Authors | |
|---|---|
| Year of publication | 2021 |
| Type | Article in Periodical |
| Magazine / Source | Revue neurologique |
| MU Faculty or unit | |
| Citation | |
| web | https://www.sciencedirect.com/science/article/pii/S0035378721005580?via%3Dihub |
| Doi | http://dx.doi.org/10.1016/j.neurol.2020.12.009 |
| Keywords | adenocarcinoma; Creutzfeldt-Jakob disease |
| Description | A 54-year-old female with a known pulmonary adenocarcinoma presented with rapid memory and language disturbances, she was anosognostic and apathetic with a Mini-Mental State Exam score 24/30. MRI showed parieto-occipital cortical ribboning in diffusion-weighted sequences (DWI) (Fig. 1A); cerebrospinal fluid (CSF) analysis found normal proteinorhachia (0,48 g/l), highly increased total tau (1481 ng/ml, N 116–370) and negative protein 14-3-3; testing for paraneoplastic antibodies (anti-Hu, Yo, Ri, CV2, PNMa2/Ta, amphiphysin) and antibodies associated with autoimmune limbic encephalitis (anti-NMDAR, AMPAR, CASPR2, LGI, GABABR) was negative. EEGs were nonspecific. Intravenous methylprednisolone and immunoglobulins were ineffective. |