Publication details
Analgeticko-myorelaxační infuze v terapii vertebrogenního algického syndromu – technologické a klinické aspekty
| Title in English | Analgesic-muscle relaxant infusion in back pain therapy – technological and clinical aspects |
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| Authors | |
| Year of publication | 2021 |
| Type | Article in Periodical |
| Magazine / Source | Ceska a Slovenska Neurologie a Neurochirurgie |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2021-5-5/analgesic-muscle-relaxant-infusion-in-back-pain-therapy-technological-and-clinical-aspects-128682 |
| Doi | http://dx.doi.org/10.48095/cccsnn2021465 |
| Keywords | analgesics; Back pain; infusion therapy; muscle relaxants; oral therapy; stability study |
| Description | Aim: The aim was to clarify the constituents and the method of administration of analgesic-muscle relaxant infusions (AMIs) routinely used in clinical practice, to rationalise individual components in AMIs, and to evaluate the compatibility and stability of the most often used AMI components. Methods: In the form of a questionnaire survey, 15 randomly selected clinical departments were contacted to obtain an overview of the spectrum of AMIs used in the Czech Republic. The rationality of the composition of AMIs was evaluated based on an assessment of the pharmacological and pharmaceutical properties of the drugs and the evidence for their use in back pain therapy. Furthermore, a compatibility and stability study of the two most often used AMIs (mixture No. 1: Trimecaine, metamizole, guaifenesin; mixture No. 2: Trimecaine, metamizole, magnesium sulfate) was conducted. Results: A large number of different combinations of drugs was found to be used, most often from the group of analgesics, muscle relaxants, corticosteroids, and local anaesthetics. The composition of AMIs proved not to be always completely rational, both from a pharmacotherapeutic (efficacy, safety, evidence) and technological (compatibility, stability) point of view. The performed technological study then proved the compatibility and stability of the two most frequently used mixtures. Conclusions: The established use of AMIs has a number of significant shortcomings. Therefore, in most cases and for a variety of reasons, oral administration of drugs seems to be more appropriate for the treatment of back pain. Intravenous therapy could thus be reserved for specific situations. |