Publication details

Mass Spectrometry Imaging Techniques Enabling Visualization of Lipid Isomers in Biological Tissues

Authors

BEDNAŘÍK Antonín PRYSIAZHNYI Vadym BEZDEKOVÁ Dominika SOLTWISCH Jens DREISEWERD Klaus PREISLER Jan

Year of publication 2022
Type Article in Periodical
Magazine / Source Analytical Chemistry
MU Faculty or unit

Faculty of Science

Citation
Web https://pubs.acs.org/doi/10.1021/acs.analchem.1c05108
Doi http://dx.doi.org/10.1021/acs.analchem.1c05108
Keywords mass spectrometry imaging; lipid isomers; double bond position; sn-position; chemical derivatization; biological tissues
Description The feature article focuses on a review of recent developments in mass spectrometry imaging (MSI) of lipid isomers in biological tissues. The tandem MS techniques utilizing on-line and off-line chemical derivatization procedures, ion activation techniques such as ozone-induced dissociation (OzID), ultraviolet photodissociation (UVPD), or electron-induced dissociation (EID), and other techniques such as coupling of ion mobility with MSI are discussed. The importance of resolving lipid isomers in diseases is highlighted.
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