Publication details

Etiopatogeneze a diagnostika progresivní multifokální leukoencefalopatie u pacientů léčených natalizumabem

Title in English Etiopathogenesis and diagnostics of progressive multifocal leukoencephalopathy in patients treated with natalizumab
Authors

ŠTOURAČ Pavel BEDNAROVA J. PAVELEK Z.

Year of publication 2021
Type Article in Periodical
Magazine / Source Ceska a slovenska neurologie a neurochirurgie
MU Faculty or unit

Faculty of Medicine

Citation
web https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2021-2-7/etiopathogenesis-and-diagnostics-of-progressive-multifocal-leukoencephalopathy-in-patients-treated-with-natalizumab-127025?hl=cs
Doi http://dx.doi.org/10.48095/cccsnn2021135
Keywords etiopathogenesis; progressive multifocal; leukoencephalopathy; natalizumab
Description Etiological agent of progressive multifocal leukoencephalopathy (PML) is polyomavirus JCV (John Cunnigham virus). PML occurs in immunosuppressed patients including MS patients treated with disease-modifying drugs. Activation of JCV in the nervous system and PML development is the result of dysregulation of genetic and immune cell mechanisms. The implementation of the safety treatment algorithm based on the length of treatment previous immunosuppressive drug treatment and positivity of the JCV antibody index is beneficial in natalizumab treated patients from the clinical point of view. Simultaneously with the use of MRI, the diagnosis of PML can be made in the preclinical phase of the disease and the prognosis of the disease can be improved.

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