Publication details

1,5-dicaffeoylquinic acid, an antioxidant component of Cynara cardunculus leaves

Authors

SLANINA Jiří PAULOVÁ Hana HUMPA Otakar BOCHOŘÁKOVÁ Hana TÁBORSKÁ Eva

Year of publication 1999
Type Article in Periodical
Magazine / Source Scripta Medica (BRNO)
MU Faculty or unit

Faculty of Medicine

Citation
Field Organic chemistry
Description This study describes the isolation, identification and some antioxidant properties of 1,5-dicaffeoylquinic acid. The title compound was isolated from the methanolic extract of the leaves of Cynara cardunculus. The isolation was based on the selective extraction of 1,5-dicaffeoylquinic acid with diethylether from weakly acidic water-methanolic solution and on column chromatography. Its structure was elucidated by 1D and 2D H-NMR spectroscopy. Inhibition of hemolysis induced by hydrogen peroxide and the antiradical effect of both 1,5-dicaffeoylquinic acid and cynarin (1,3-dicaffeoylquinic acid) were studied. Cynarin is formed from 1,5-dicaffeoylquinic acid by transesterification during the solvent extraction. Antioxidant activity of dicaffeoylquinic acids in both systems was stronger than that of ascorbic acid.

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