Publication details

Tolerated variations in a genome - The case of closely related Bacillus phages PZA, phi 29, and phi 15. A review.

Authors

PAČES V. VLČEK Č. ŠMARDA Jan ZADRAŽIL S. FUČÍK V.

Year of publication 1987
Type Article in Periodical
Magazine / Source Gene
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords phi29;PZA
Description Restriction-site analysis was used to estimate the relationship of bacteriophages PZA, phi 29 and phi 15. Complete nucleotide sequences of PZA and luminal diameter 29 genomes were compared and tolerated variations were assessed. Most of the base-pair changes are silent nucleotide substitutions in the third position of codons but amino acid changing substitutions are also observed. The terminal portions of the phage genomes diverged faster than their central parts. Gene mutations in phage PZA were induced by hydroxylamine and their frequency was compared with the evolutionary mutability.

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