Publication details
Study of Biological Activity of Novel Hydroxamic Acids Derived From Vorinostat as the Inhibitor of Histone Deacetylases
| Authors | |
|---|---|
| Year of publication | 2022 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Histone deacetylase inhibitors (iHDACs), a class of epigenetic regulators, are substances with anticancer activity that is associated with inhibition of cell proliferation, induction of programmed cell death, inhibition of angiogenesis, and induction of the cytodifferentiation process in cancer cells. Hydroxamic acid derivatives are currently the most important group of iHDACs. Our study was focused on the evaluation of biological activity of new hydroxamic acids derivates as potential iHDACs designed and synthesised by the Department of Chemical Drugs in Faculty of Pharmacy at Masaryk University. |
| Related projects: |