Registry-based analysis of Icatibant and C1-inhibitor use in treatment of laryngeal attacks of hereditary angioedema

• Authors: HAKL Roman; KUKLÍNEK Pavel; SOBOTKOVA Marta; KRCMOVA Irena; KRALICKOVA Pavlina; VACHOVA Martina; HANZLIKOVA Jana; NOVACKOVA Martina; SVOBODA Michal; KOVÁČOVÁ Ingrid; LITZMAN Jiří
• Year of publication: 2022
• Type: Article in Periodical
• Magazine / Source: CLINICAL AND EXPERIMENTAL ALLERGY
• MU Faculty or unit: Faculty of Medicine
• Web: https://onlinelibrary.wiley.com/doi/10.1111/cea.14182
• Doi: http://dx.doi.org/10.1111/cea.14182
• Keywords: Icatibant; C1-inhibitor; hereditary angioedema; laryngeal attacks
• Description: Hereditary angioedema (HAE) is a rare condition which manifests as repeated episodes of localized subcutaneous or submucosal oedema. Oedemas involving the upper airways carry the risk of asphyxiation and death. The aim of this study was to present our clinical experience of icatibant and C1 inhibitor use for treating HAE-1/2 laryngeal attacks (LA). To our knowledge, this is the first direct comparison of these treatment approaches for LA.