Publication details
Duální opioidní analgezie
| Title in English | Dual opioid analgesia |
|---|---|
| Authors | |
| Year of publication | 2022 |
| Type | Article in Periodical |
| Magazine / Source | Farmacie pro praxi - Praktické lékárenství |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.praktickelekarenstvi.cz/artkey/lek-202201-0007_dualni_opioidni_analgezie.php |
| Doi | http://dx.doi.org/10.36290/lek.2022.007 |
| Keywords | opioid receptors; pain management; opioids; dual opioid analgesia |
| Description | Current opioid analgesics are agonists or partial agonists of the opioid receptors µ, ?, ?, and ORL1 (MOPr, DOPr, KOPr, and NOPr.) The combination of agonists and partial agonists or two full agonists with different receptor affinities should theoretically reduce the potential of maximal analgesic effect. However, in clinical practice, these combinations are particularly effective in increasing analgesic efficacy, better tolerability, better control of pain intensity during the day, and delaying tolerance to the analgesic effect. The article provides an overview of the current state of knowledge about dual opioid analgesia and pharmacological arguments supporting the rationality of these combinations. Nevertheless, it should be emphasized that the combination of opioids is not recommended practice but rather an alternative approach in the case of failure of the standard treatment accordingly to the current clinical guidelines |
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