Publication details

Klinické důsledky mutací genu CBP

Title in English Clinical consequence of CBP gene mutation
Authors

ŠMARDOVÁ Jana ŠMARDA Jan

Year of publication 1999
Type Article in Periodical
Magazine / Source Časopis lékařů českých
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords CBP
Description CBP is transcriptional coactivator that can interact with many transcription factors. It modifies the process of transcription stimulated by these factors by specific binding to RNA polymerase II holoenzyme or by histone acetylation. CBP gene mutation is the molecular cause of autosomal dominant genetic disease called Rubinstein-Taybi syndrome.
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