Publication details

Letermovir u pacientů po alogenní transplantaci krvetvorných buněk – přehled literatury

Title in English Letermovir in patients after allogeneic haematopoietic stem cell transplantation – literature review
Authors

KABUT Tomáš WEINBERGEROVÁ Barbora LENGEROVÁ Martina FOLBER František MAYER Jiří

Year of publication 2022
Type Article in Periodical
Magazine / Source Transfuze a Hematologie Dnes
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.prolekare.cz/casopisy/transfuze-hematologie-dnes/2022-1-14/letermovir-u-pacientu-po-alogenni-transplantaci-krvetvornych-bunek-prehled-literatury-130300
Doi http://dx.doi.org/10.48095/cctahd20227
Keywords Prophylaxis; cytomegalovirus; letermovir; allogeneic haematopoietic stem cell transplant
Description Cytomegalovirus (CMV) reactivation after allogeneic haematopoietic stem cell transplantation and its subsequent antiviral treatment is a significant complication leading to increased morbidity and mortality in these patients. Frequent monitoring of CMV viremia with early pre-emptive antiviral treatment in case of CMV reactivation represents the most widely used option to date for preventing CMV disease. While this approach leads to a low incidence of CMV disease, the percentage of CMV reactivations requiring pre-emptive therapy remains high and increased morbidity and non-relapse mortality are thus associated with CMV reactivation per se. Letermovir is a new antiviral drug with anti-CMV activity approved for use in CMV seropositive patients after allogeneic hematopoietic stem cell transplantation. A randomized, placebo-controlled study that led to the introduction of letermovir into clinical practice demonstrated a positive effect in reducing the incidence of clinically significant CMV infection as well as non-relapse mortality compared to placebo, especially in patients at high risk of CMV disease. Although it is already commonly used in primary CMV prophylaxis after allogeneic hematopoietic transplantation, its use is associated with certain unresolved issues such as the optimal duration of prophylaxis or its use in secondary prophylaxis or pre-emptive treatment of CMV reactivation. The following article summarizes currently available data on the use of letermovir in patients after allogeneic hematopoietic stem cell transplantation.

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