Publication details

Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer

Authors

SVATON Martin DROSSLEROVA Marie FISCHER Ondrej MAREL Miloslav HRNCIARIK Michal VENCLÍČEK Ondřej ZUNA Petr SVOBODA Michal BLAZEK Jiri BRATOVÁ Monika MULLEROVA Andrea VANKOVA Bohuslava KREJCI Daniel

Year of publication 2022
Type Article in Periodical
Magazine / Source TRANSLATIONAL CANCER RESEARCH
MU Faculty or unit

Faculty of Medicine

Citation
web https://tcr.amegroups.com/article/view/66943/html
Doi http://dx.doi.org/10.21037/tcr-22-260
Keywords Non-small cell lung cancer (NSCLC); lung cancer; programmed death-ligand 1 (PD-L1); non-steroidal anti-inflammatory drugs (NSAIDs); corticosteroids
Description Background: Programmed death-ligand 1 (PD-L1) expression is a standard predictor in the selection of immunotherapy for locally advanced/advanced non-small cell lung cancer (NSCLC). However, comedication with corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs) may influence the effectiveness of this treatment as documented in several previous studies. Due to certain molecular linkages between PD-L1 and corticosteroids or NSAIDs, we therefore addressed the question of whether there is a relationship between PD-L1 expression in NSCLC and the use of this comedication. Methods: This is a retrospective study using the Czech tumor registry LUng CAncer focuS (LUCAS), from which patient data were drawn. Independence of two categorical parameters was tested by Pearson's chi-square test. Results: In our group of 1,148 patients, we observed no significant relationship between PD-L1 expression and the use of corticosteroids or NSAIDs. Conclusions: According to our data, treatment with corticosteroids or NSAIDs during biopsy does not affect the expression of PD-L1 and it is therefore not necessary to take this treatment into account in this regard.

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