Publication details

PDBe and PDBe-KB: Providing high-quality, up-to-date and integrated resources of macromolecular structures to support basic and applied research and education

Authors	VARADI Mihaly ANYANGO Stephen APPASAMY Sri Devan ARMSTRONG David BAGE Marcus BERRISFORD John CHOUDHARY Preeti BERTONI Damian DESHPANDE Mandar LEINES Grisell Diaz ELLAWAY Joseph EVANS Genevieve GÁBOROVÁ Romana GUPTA Deepti GUTMANAS Aleksandras HARRUS Deborah KLEYWEGT Gerard J BUENO Weslley Morellato NADZIRIN Nurul NAIR Sreenath PRAVDA Lukas AFONSO Marcelo Querino Lima SEHNAL David TANWEER Ahsan TOLCHARD James ABRAMS Charlotte DUNLOP Roisin VELANKAR Sameer
Year of publication	2022
Type	Article in Periodical
Magazine / Source	Protein Science
MU Faculty or unit	Faculty of Science
Citation
Web	https://onlinelibrary.wiley.com/doi/10.1002/pro.4439
Doi	http://dx.doi.org/10.1002/pro.4439
Keywords	bioinformatics; databases; protein data bank; structural biology
Description	The archiving and dissemination of protein and nucleic acid structures as well as their structural, functional and biophysical annotations is an essential task that enables the broader scientific community to conduct impactful research in multiple fields of the life sciences. The Protein Data Bank in Europe (PDBe; ) team develops and maintains several databases and web services to address this fundamental need. From data archiving as a member of the Worldwide PDB consortium (wwPDB; ), to the PDBe Knowledge Base (PDBe-KB; ), we provide data, data-access mechanisms, and visualizations that facilitate basic and applied research and education across the life sciences. Here, we provide an overview of the structural data and annotations that we integrate and make freely available. We describe the web services and data visualization tools we offer, and provide information on how to effectively use or even further develop them. Finally, we discuss the direction of our data services, and how we aim to tackle new challenges that arise from the recent, unprecedented advances in the field of structure determination and protein structure modeling.