Publication details
The Effectiveness of Mobile-based Psychological Interventions in Reducing Psychological Distress and Preventing Stress-related Changes in Psychoneuroendocrine- immune Network in Breast Cancer Survivors- Randomized Controlled Trial - Clinical Trial Protocol Registration
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| Year of publication | 2022 |
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| Description | In this study researchers will examine an influence of three different psychological interventions in the form of mobile application on psychoneuroendocrine- immune system among breast cancer survivors. Most studies focusing on the effects of psychological interventions on healthrelated outcomes have relied on self-reports. There is also growing research interest in the effects of such interventions on directly measurable biological processes associated with chronic stress. Neuroendocrine-immune system interactions are fundamental tools through which stress affects the course of cancer. The study will examine effect of three psychological interventions on most frequently studied stress related biomarkers: cortisol, HRV (heartrate variability), CRP, relative and absolute counts of: B-lymphocytes ,Tlymphocytes, NK-cells, NK-T-like cells, monocytes; cytokine levels. Although current research suggests salutogenic changes in the immune profile of cancer patients as a result of psychological interventions, the results of individual studies are still inconsistent. To get clearer outcomes researchers decided to follow recommendations for researchers in manner that optimizes study design: to recruit very homogenous sample of cancer patients, to continue measurements in 3 and 9 months follow up, to collect data on individual´s adherence to protocol of mobile application.1,2 In addition to biomarkers, researchers will monitor changes in psychological variables. |
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