Clonal competition and disrupted molecular processes in chronic lymphocytic leukemia.

• Authors: ZÁVACKÁ Kristýna; TAUŠ Petr; PÁL Karol; PORC Jakub Paweł; PAVLOVÁ Šárka; MALČÍKOVÁ Jitka; STRÁNSKÁ Kamila; ŽENATOVÁ Marcela; TICHÝ Boris; BLAVET Nicolas; PANOVSKÁ Anna; DOUBEK Michael; POSPÍŠILOVÁ Šárka; PLEVOVÁ Karla
• Year of publication: 2023
• Type: Conference abstract
• MU Faculty or unit: Central European Institute of Technology

Attached files

• FEBS-Biochemistry_Congress_final_programme_abstract_book.pdf

• Description: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries. Due to dynamic clonal changes in a leukemic cell population over time, CLL is characterized by a highly variable clinical course. The expansion of subclones with different gene mutations, many of which are non-recurrent, makes CLL challenging to treat. We aimed to describe the clonal evolution in CLL, focusing on specific treatments and different stages of the disease. As defects in the TP53 gene are strong predictive and prognostic markers in CLL and drive chemoimmunotherapy resistance, we particularly studied factors influencing the clonal development of TP53-mutated subclones.

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