Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe

• Authors: LAURA Rodriguez Martin; GILLES Liese; HELTE Emilie; AKESSON Agneta; TAGT Jonas; COVACI Adrian; SAKHI Amrit K.; VAN NIEUWENHUYSE An; KATSONOURI Andromachi; ANDERSSON Anna-Maria; GUTLEB Arno C.; JANASIK Beata; APPENZELLER Brice; GABRIEL Catherine; THOMSEN Cathrine; MAZEJ Darja; SARIGIANNIS Denis; ANASTASI Elena; BARBONE Fabio; TOLONEN Hanna; FREDERIKSEN Hanne; KLÁNOVÁ Jana; KOPONEN Jani; TRATNIK Janja Snoj; PACK Kim; GUDRUN Koppen; OLAFSDOTTIR Kristin; KNUDSEN Lisbeth E.; RAMBAUD Loic; STRUMYLAITE Loreta; MURINOVA Lubica Palkovicova; FABELOVA Lucia; RIOU Margaux; BERGLUND Marika; SZABADOS Mate; IMBODEN Medea; LAEREMANS Michelle; ESTOKOVA Milada; HOLCER Natasa Janev; PROBST-HENSCH Nicole; VODRAZKOVA Nicole; VOGEL Nina; PILER Pavel; SCHMIDT Phillipp; LANGE Rosa; NAMORADO Sonia; KOZEPESY Szilvia; SZIGETI Tamas; HALLDORSSON Thorhallur I.; WEBER Till; JENSEN Tina Kold; ROSOLEN Valentina; PUKLOVA Vladimira; WASOWICZ Wojciech; SEPAI Ovnair; STEWART Lorraine; KOLOSSA-GEHRING Marike; ESTEBAN-LOPEZ Marta; CASTANO Argelia; BESSEMS Jos; SCHOETERS Greet; GOVARTS Eva
• Year of publication: 2023
• Type: Article in Periodical
• Magazine / Source: Toxics
• MU Faculty or unit: Faculty of Science
• Web: https://www.mdpi.com/2305-6304/11/10/819
• Doi: http://dx.doi.org/10.3390/toxics11100819
• Keywords: human biomonitoring; hazardous chemical; phthalates; DINCH; OPFRs; cadmium; PAHs; bisphenols

Attached files

• 2345842.pdf

• Description: Human biomonitoring (HBM) data in Europe are often fragmented and collected in different EU countries and sampling periods. Exposure levels for children and adult women in Europe were evaluated over time. For the period 2000-2010, literature and aggregated data were collected in a harmonized way across studies. Between 2011-2012, biobanked samples from the DEMOCOPHES project were used. For 2014-2021, HBM data were generated within the HBM4EU Aligned Studies. Time patterns on internal exposure were evaluated visually and statistically using the 50th and 90th percentiles (P50/P90) for phthalates/DINCH and organophosphorus flame retardants (OPFRs) in children (5-12 years), and cadmium, bisphenols and polycyclic aromatic hydrocarbons (PAHs) in women (24-52 years). Restricted phthalate metabolites show decreasing patterns for children. Phthalate substitute, DINCH, shows a non-significant increasing pattern. For OPFRs, no trends were statistically significant. For women, BPA shows a clear decreasing pattern, while substitutes BPF and BPS show an increasing pattern coinciding with the BPA restrictions introduced. No clear patterns are observed for PAHs or cadmium. Although the causal relations were not studied as such, exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. The results support policy efficacy monitoring and the policy-supportive role played by HBM.

Related projects

• European Human Biomonitoring Initiative