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Amphiphilic Sialic Acid Derivatives as Potential Dual-Specific Inhibitors of Influenza Hemagglutinin and Neuraminidase
Authors | |
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Year of publication | 2023 |
Type | Article in Periodical |
Magazine / Source | International Journal of Molecular Sciences |
MU Faculty or unit | |
Citation | |
Web | https://www.mdpi.com/1422-0067/24/24/17268 |
Doi | http://dx.doi.org/10.3390/ijms242417268 |
Keywords | influenza; sialic acid; neuraminidase; hemagglutinin; aggregates |
Description | Blocking viral hemagglutinin with multivalent N-acetylneuraminic acid derivatives is a promising approach to prevent influenza infection. Moreover, dual inhibition of both hemagglutinin and neuraminidase may result in a more powerful effect. Since both viral glycoproteins can bind to neuraminic acid, we have prepared three series of amphiphilic self-assembling 2-thio-neuraminic acid derivatives constituting aggregates in aqueous medium to take advantage of their multivalent effect. One of the series was prepared by the azide-alkyne click reaction, and the other two by the thio-click reaction to yield neuraminic acid derivatives containing lipophilic tails of different sizes and an enzymatically stable thioglycosidic bond. Two of the three bis-octyl derivatives produced proved to be active against influenza viruses, while all three octyl derivatives bound to hemagglutinin and neuraminidase from H1N1 and H3N2 influenza types. |
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