Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function.

• Authors: PEŠOVÁ Michaela; MANČÍKOVÁ Veronika; HELMA Robert; PAVLOVÁ Šárka; HEJRET Václav; TAUŠ Petr; HYNŠT Jakub; PLEVOVÁ Karla; KOTAŠKOVÁ Jana; MALČÍKOVÁ Jitka; POSPÍŠILOVÁ Šárka
• Year of publication: 2023
• Type: Conference abstract
• MU Faculty or unit: Central European Institute of Technology

Attached files

• Abstract_book_Joint_PhDPostDocRETREAT_2023.pdf

• Description: Protein p53 has a central role in tumor suppression. Under normal conditions, p53 levels are kept low, but in response to DNA damage, p53 becomes stabilized and initiates the transcription of its target genes. In chronic lymphocytic leukemia (CLL), aberrations in the TP53 gene are associated with the aggressive disease since the function of p53 protein is impaired. However, the p53 function might also be disrupted by other mechanisms, e.g. altered phosphorylation, even in the wild-type protein. Therefore, we aimed to investigate the impact of p53 phosphorylation on p53 function in CLL and uncover what underlies the existence of possible different phosphorylation patterns.

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