Publication details
Příprava a hodnocení sprejově sušených inhalovatelných mikročástic ze směsí nosičů
| Title in English | Preparation and evaluation of spray-dried inhalable microparticles from carrier mixtures |
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| Authors | |
| Year of publication | 2023 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská farmacie |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.prolekare.cz/en/journals/czech-and-slovak-pharmacy/2023-5-12/priprava-a-hodnoceni-sprejove-susenych-inhalovatelnych-mikrocastic-ze-smesi-nosicu-136102/download?hl=cs |
| Keywords | inhalation administration; microparticles; carriers; mixtures; spray drying |
| Description | The formulation of microparticles composed of a mixture of carriers represents an innovative approach for lung drug delivery of dry powder. The carriers used can significantly influence the properties of the microparticles, such as size, shape, surface area, hygroscopicity, or aggregation, thus improving the aerosolization of the drugs after inhalation. The properties mentioned above are crucial for effective pulmonary therapy. The combination of carriers of a carbohydrate nature and gelling agents is advantageous for controlled drug release. The experimental work aimed to prepare by spray drying and subsequently evaluate ten batches of microparticles composed of sugar-based carriers (mannitol, maltodextrin, dextran) and gelling polymers (chitosan, chondroitin sulfate) and to select a suitable combination for follow-up experimental work aimed at drug incorporation into the microparticle matrix. The most suitable parameters were exhibited by batches whose aerodynamic diameter was close to 5 µm, particles prepared from a combination of mannitol and dextran, chitosan and chondroitin, or maltodextrin and chondroitin. These batches also showed the highest fine particle fraction value (> 43%). From a processability point of view, the batch with maltodextrin and chondroitin is preferable due to the lower viscosity of the dispersion and the more regular shape of the final microparticles. |
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