Publication details

Telomerase RNA gene paralogs in plants - the usual pathway to unusual telomeres

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Authors

ZÁVODNÍK Michal FAJKUS Petr FRANEK Michal KOPECKÝ David GARCIA Sonia DODSWORTH Steven OREJUELA Andres KILAR Agata Magdalena PTACEK Jiri MÁTL Martin HÝSKOVÁ Anna FAJKUS Jiří PEŠKA Vratislav

Year of publication 2023
Type Article in Periodical
Magazine / Source New Phytologist
MU Faculty or unit

Central European Institute of Technology

Citation
Web https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.19110
Doi http://dx.doi.org/10.1111/nph.19110
Keywords evolution; land plants; mechanism of telomere transitions; telomerase RNA paralogs; unusual telomere DNA
Attached files
Description Telomerase, telomeric DNA and associated proteins together represent a complex, finely tuned and functionally conserved mechanism that ensures genome integrity by protecting and maintaining chromosome ends. Changes in its components can threaten an organism's viability. Nevertheless, molecular innovation in telomere maintenance has occurred multiple times during eukaryote evolution, giving rise to species/taxa with unusual telomeric DNA sequences, telomerase components or telomerase-independent telomere maintenance. The central component of telomere maintenance machinery is telomerase RNA (TR) as it templates telomere DNA synthesis, its mutation can change telomere DNA and disrupt its recognition by telomere proteins, thereby leading to collapse of their end-protective and telomerase recruitment functions.
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