Publication details
Prenylované rostlinné fenoly jako modulátory buněčné komunikace
| Title in English | Prenylated plant phenolics as modulators of intercellular communication |
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| Year of publication | 2023 |
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| Description | Prenylated phenolics are secondary plant metabolites with many interesting properties. Their anti-inflammatory and antioxidant effects support the maintenance of tissue homeostasis, where intercellular communication plays a key role. One of the most important types of this communication is gap junctional intercellular communication (GJIC). The proper functioning of GJIC is strictly regulated, as its activity is associated with important signaling pathways in cells. However, dysregulation of GJIC has been linked to various pathophysiological conditions, such as cancer. Substances that demonstrate the ability to restore GJIC can be considered potentially anticarcinogenic. Therefore, GJIC may represent not only a potential pharmacological and therapeutic target but also an important process utilized in studying and screening the biological activity of natural compounds, especially those with potential antioxidant effects. In this project, prenylated phenolics obtained from Paulownia tomentosa were tested. Their effects on intercellular communication in the tumorigenic cell line WB-ras and the effects on the 3D tumor spheroids growth were observed. The result of the experiments is a set of compounds that showed positive stimulation of GJIC and significantly affected the growth of cell spheroids. |
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