Publication details

Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

Authors

KURSVIETIENE Lolita KOPUSTINSKIENE Dalia M STANEVICIENE Inga MONGIRDIENE Ausra KUBOVÁ Kateřina MASTEIKOVÁ Ruta BERNATONIENE Jurga

Year of publication 2023
Type Article in Periodical
Magazine / Source Antioxidants
MU Faculty or unit

Faculty of Pharmacy

Citation
web https://www.mdpi.com/2076-3921/12/12/2056
Doi http://dx.doi.org/10.3390/antiox12122056
Keywords resveratrol; cancer; mitochondria
Description Cancer is one of the most serious public health issues worldwide, demanding ongoing efforts to find novel therapeutic agents and approaches. Amid growing interest in the oncological applications of phytochemicals, particularly polyphenols, resveratrol-a naturally occurring polyphenolic stilbene derivative-has emerged as a candidate of interest. This review analyzes the pleiotropic anti-cancer effects of resveratrol, including its modulation of apoptotic pathways, cell cycle regulation, inflammation, angiogenesis, and metastasis, its interaction with cancer stem cells and the tumor microenvironment. The effects of resveratrol on mitochondrial functions, which are crucial to cancer development, are also discussed. Future research directions are identified, including the elucidation of specific molecular targets, to facilitate the clinical translation of resveratrol in cancer prevention and therapy.

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