Structural conservation of antibiotic interaction with ribosomes

• Authors: PATERNOGA Helge; CROWE-MCAULIFFE Caillan; BOCK Lars V; KOLLER Timm O; MORICI Martino; BECKERT Bertrand; MYASNIKOV Alexander G; GRUBMUELLER Helmut; NOVÁČEK Jiří; WILSON Daniel N
• Year of publication: 2023
• Type: Article in Periodical
• Magazine / Source: NATURE STRUCTURAL & MOLECULAR BIOLOGY
• MU Faculty or unit: Central European Institute of Technology
• Web: https://www.nature.com/articles/s41594-023-01047-y
• Doi: http://dx.doi.org/10.1038/s41594-023-01047-y
• Keywords: ribosome; antibiotics; CryoEM; antibiotic–ribosome interactions; RNA-targeting therapies
• Description: Here the authors present the high-resolution structures of 17 antibiotics bound to Escherichia coli ribosomes, which may inform the development of new antibacterial agents. Their results unveil a conserved manner of antibiotic binding to the ribosome, including ordered water molecules.

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