The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories A Systematic Analysis for the Global Burden of Disease Study 2019
| Authors |
RAMOS da Cunha Amanda COMPTON Kelly XU Rixing MISHRA Rashmi DRANGSHOLT Mark Thomas ANTUNES Jose Leopoldo Ferreira KERR Alexander R ACHESON Alistair R LU Dan WALLACE Lindsey E KOCARNIK Jonathan M FU Weijia DEAN Frances E PENNINI Alyssa HENRIKSON Hannah Jacqueline ALAM Tahiya ABABNEH Emad ABD-ELSALAM Sherief ABDOUN Meriem ABIDI Hassan HIWA Abubaker Ali ABU-GHARBIEH Eman ADANE Tigist Demssew ADDO Isaac Yeboah AHMAD Aqeel AHMAD Sajjad TARIK Ahmed Rashid AKONDE Maxwell HANADI Al Hamad ALAHDAB Fares ALIMOHAMADI Yousef ALIPOUR Vahid AL-MAWERI Sadeq Ali ALSHARIF Ubai ANSARI-MOGHADDAM Alireza ANWAR Sumadi Lukman ANYASODOR Anayochukwu Edward ARABLOO Jalal ARAVKIN Aleksandr Y ARULEBA Raphael Taiwo ASAAD Malke ASHRAF Tahira ATHARI Seyyed Shamsadin ATTIA Sameh AZADNAJAFABAD Sina AZANGOU-KHYAVY Mohammadreza BADAR Muhammad BAGHCHEGHI Nayereh BANACH Maciej BARDHAN Mainak BARQAWI Hiba Jawdat BASHIR Nasir Z BASHIRI Azadeh BENZIAN Habib BERNABE Eduardo BHAGAT Devidas S BHOJARAJA Vijayalakshmi S BJORGE Tone BOUAOUD Souad BRAITHWAITE Dejana BRIKO Nikolay Ivanovich CALINA Daniela CARRERAS Giulia CHAKRABORTY Promit Ananyo CHATTU Vijay Kumar CHAURASIA Akhilanand CHEN Meng Xuan CHO William C S CHU Dinh-Toi CHUKWU Isaac Sunday CHUNG Eunice CRUZ-MARTINS Natalia DADRAS Omid DAI Xiaochen DANDONA Lalit DANDONA Rakhi DANESHPAJOUHNEJAD Parnaz REZA Darvishi Cheshmeh Soltani DARWESH Aso Mohammad DEBELA Sisay Abebe MESERET Derbew Molla DESSALEGN Fikadu Nugusu DIANATI-NASAB Mostafa DIGESA Lankamo Ena DIXIT Shilpi Gupta DIXIT Abhinav DJALALINIA Shirin IMAN El Sayed MAHA El Tantawi ENYEW Daniel Berhanie ERKU Daniel Asfaw EZZEDDINI Rana FAGBAMIGBE Adeniyi Francis FALZONE Luca FETENSA Getahun FUKUMOTO Takeshi GAEWKHIEW Piyada GALLUS Silvano GEBREHIWOT Mesfin GHASHGHAEE Ahmad GILL Paramjit Singh GOLECHHA Mahaveer GOLEIJ Pouya GOMEZ Ricardo Santiago GORINI Giuseppe GUIMARAES Andre Luiz Sena GUPTA Bhawna GUPTA Sapna GUPTA Veer Bala GUPTA Vivek Kumar HAJ-MIRZAIAN Arvin HALBOUB Esam S HALWANI Rabih HANIF Asif HARIYANI Ninuk HARORANI Mehdi HASANI Hamidreza HASSAN Abbas M HASSANIPOUR Soheil HASSEN Mohammed Bheser HAY Simon I HAYAT Khezar HERRERA-SERNA Brenda Yuliana HOLLA Ramesh HORITA Nobuyuki HOSSEINZADEH Mehdi HUSSAIN Mohammad Salman ILESANMI Olayinka Stephen ILIC Irena M ILIC Milena D ISOLA Gaetano JAISWAL Abhishek JANI Chinmay T JAVAHERI Tahereh JAYARAJAH Umesh JAYARAM Shubha JOSEPH Nitin KADASHETTI Vidya KANDASWAMY Eswar KARANTH Shama D KARAYE Ibraheem M KAUPPILA Joonas H KAUR Harkiran KEYKHAEI Mohammad KHADER Yousef Saleh KHAJURIA Himanshu KHANALI Javad KHATIB Mahalaqua Nazli REZA Khayat Kashani Hamid AMIN Khazeei Tabari Mohammad KIM Min Seo KOMPANI Farzad KOOHESTANI Hamid Reza KUMAR G Anil KURMI Om P CARLO La Vecchia LAL Dharmesh Kumar LANDIRES Ivan LASRADO Savita LEDDA Caterina LEE Yo Han LIBRA Massimo LIM Stephen S LISTL Stefan LOPUKHOV Platon D MAFI Ahmad R MAHUMUD Rashidul Alam MALIK Ahmad Azam MATHUR Manu Raj MAULUD Sazan Qadir MEENA Jitendra Kumar ENTEZAR Mehrabi Nasab MESTROVIC Tomislav MIRFAKHRAIE Reza MISGANAW Awoke MISRA Sanjeev MITHRA Prasanna MOHAMMAD Yousef MOHAMMADI Mokhtar MOHAMMADI Esmaeil MOKDAD Ali H MONI Mohammad Ali MORAGA Paula MORRISON Shane Douglas MOZAFFARI Hamid Reza MUBARIK Sumaira MURRAY Christopher J L NAIR Tapas Sadasivan SREENIVAS Narasimha Swamy NARAYANA Aparna Ichalangod NASSERELDINE Hasan NATTO Zuhair S NAYAK Biswa Prakash NEGRU Serban Mircea NGGADA Haruna Asura NOURAEI Hasti NUNEZ-SAMUDIO Virginia OANCEA Bogdan OLAGUNJU Andrew T AHMED Omar Bali PADRON-MONEDERO Alicia PADUBIDRI Jagadish Rao PANDEY Anamika PARDHAN Shahina PATEL Jay PEZZANI Raffaele PIRACHA Zahra Zahid RABIEE Navid RADHAKRISHNAN Venkatraman RADHAKRISHNAN Raghu Anekal RAHMANI Amir Masoud RAHMANIAN Vahid RAO Chythra R RAO Sowmya J RATH Goura Kishor RAWAF David Laith RAWAF Salman RAWASSIZADEH Reza RAZEGHINIA Mohammad Sadegh REZAEI Nazila REZAEI Negar REZAEI Nima REZAPOUR Aziz RIAD Abanoub ROBERTS Thomas J ROMERO-RODRIGUEZ Esperanza ROSHANDEL Gholamreza MANJULA S. CHANDAN S N SADDIK Basema SAEB Mohammad Reza SAEED Umar SAFAEI Mohsen SAHEBAZZAMANI Maryam SAHEBKAR Amirhossein AMIR Salek Farrokhi SAMY Abdallah M SANTRIC-MILICEVIC Milena M SATHIAN Brijesh SATPATHY Maheswar SEKERIJA Mario SENTHILKUMARAN Subramanian SEYLANI Allen SHAFAAT Omid SHAHSAVARI Hamid R SHAMSODDIN Erfan SHAREW Mequannent Melaku SHARIFI-RAD Javad SHETTY Jeevan K SHIVAKUMAR K M SHOBEIRI Parnian SHOROFI Seyed Afshin SHRESTHA Sunil SIDDAPPA Malleshappa Sudeep K. SINGH Paramdeep SINGH Jasvinder A SINGH Garima SINHA Dhirendra Narain SOLOMON Yonatan SULEMAN Muhammad RIZWAN Suliankatchi Abdulkader YASAMAN Taheri Abkenar TALAAT Iman M TAN Ker-Kan TBAKHI Abdelghani THIYAGARAJAN Arulmani TIYURI Amir TOVANI-PALONE Marcos Roberto UNNIKRISHNAN Bhaskaran BAY Vo VOLOVAT Simona Ruxandra WANG Cong WESTERMAN Ronny WICKRAMASINGHE Nuwan Darshana XIAO Hong YU Chuanhua YUCE Deniz YUNUSA Ismaeel ZADNIK Vesna ZARE Iman ZHANG Zhi-Jiang ZOLADL Mohammad FORCE Lisa M HUGO Fernando N |
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| Year of publication | 2023 |
| Type | Article in Periodical |
| Magazine / Source | JAMA ONCOLOGY |
| MU Faculty or unit | |
| Citation | |
| Web | https://jamanetwork.com/journals/jamaoncology/fullarticle/2809272 |
| Doi | http://dx.doi.org/10.1001/jamaoncol.2023.2960 |
| Keywords | lip cancer; oral cancer; pharyngeal cancer |
| Description | IMPORTANCE Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning.OBJECTIVE To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates.EVIDENCE REVIEW The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019.FINDINGS In 2019, 370 000 (95% uncertainty interval [UI], 338 000-401000) cases and 199 000 (95% UI, 181 000-217 000) deaths for LOC and 167 000 (95% UI, 153 000-180 000) cases and 114 000 (95% UI, 103 000-126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia. CONCLUSIONS AND RELEVANCE In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts. |
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