Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

• Authors: ZHOU Bin; SHEFFER Kate E; BENNETT James E; GREGG Edward W; DANAEI Goodarz; SINGLETON Rosie K; SHAW Jonathan E; MISHRA Anu; LHOSTE Victor P F; CARRILLO-LARCO Rodrigo M; KENGNE Andre P; PHELPS Nowell H; HEAP Rachel A; RAYNER Archie W; STEVENS Gretchen A; PACIOREK Chris J; RILEY Leanne M; COWAN Melanie J; SAVIN Stefan; STEPHEN Vander Hoorn; LU Yuan; PAVKOV Meda E; IMPERATORE Giuseppina; AGUILAR-SALINAS Carlos A; AHMAD Noor Ani; ANJANA Ranjit Mohan; DAVLETOV Kairat; FARZADFAR Farshad; GONZALEZ-VILLALPANDO Clicerio; KHANG Young-Ho; KIM Hyeon Chang; LAATIKAINEN Tiina; LAXMAIAH Avula; MBANYA Jean Claude N; NARAYAN K M Venkat; RAMACHANDRAN Ambady; WADE Alisha N; ZDROJEWSKI Tomasz; ABBASI-KANGEVARI Mohsen; RAHIM Hanan F Abdul; ABU-RMEILEH Niveen M; ADAMBEKOV Shalkar; ADAMS Robert J; AEKPLAKORN Wichai; AGDEPPA Imelda A; AGHAZADEH-ATTARI Javad; AGYEMANG Charles; AHMADI Ali; AHMADI Naser; AHMADI Nastaran; AHMED Soheir H; AJLOUNI Kamel; AL-HINAI Halima; AL-LAHOU Badreya; AL-LAWATI Jawad A; DEENA Al Asfoor; QAOUD Nawal M. Al; ALAROUJ Monira; ALBUHAIRAN Fadia; ALDHUKAIR Shahla; ALDWAIRJI Maryam A; ALI Mohamed M; ALINEZHAD Farbod; ALKANDARI Abdullah; ALOMIRAH Husam F; ALY Eman; AMARAPURKAR Deepak N; ANDERSEN Lars Bo; ANDERSSEN Sigmund A; ANDRADE Dolores S; ANSARI-MOGHADDAM Alireza; AOUNALLAH-SKHIRI Hajer; ARIS Tahir; ARLAPPA Nimmathota; ARYAL Krishna K; ASSAH Felix K; ASSEMBEKOV Batyrbek; AUVINEN Juha; AVDICOVA Maria; AZAD Kishwar; AZIMI-NEZHAD Mohsen; AZIZI Fereidoun; BACOPOULOU Flora; BALAKRISHNA Nagalla; BAMOSHMOOSH Mohamed; BANACH Maciej; BANDOSZ Piotr; BANEGAS Jose R; BARBAGALLO Carlo M; BARCELO Alberto; BARETIC Maja; BARRERA Lena; BASIT Abdul; BATIEHA Anwar M; BATISTA Aline P; BAUR Louise A; BELAVENDRA Antonisamy; HABIBA Ben Romdhane; BENET Mikhail; BERKINBAYEV Salim; BERNABE-ORTIZ Antonio; XIMENA Berrios Carrasola; BETTIOL Heloisa; BEYBEY Augustin F; BHARGAVA Santosh K; LELE Elysee Claude Bika; BIKBOV Mukharram M; BISTA Bihungum; BJERREGAARD Peter; BJERTNESS Espen; BJERTNESS Marius B; BJORKELUND Cecilia; BLOCH Katia V; BLOKSTRA Anneke; BO Simona; BOBÁK Martin; BOGGIA Jose G; BONACCIO Marialaura; BONILLA-VARGAS Alice; BORGHS Herman; BOVET Pascal; BRAJKOVICH Imperia; BRENNER Hermann; BREWSTER Lizzy M; BRIAN Garry R; BRICENO Yajaira; BRITO Miguel; BUGGE Anna; BUNTINX Frank; DE LEÓN Antonio Cabrera; CAIXETA Roberta B; CAN Gunay; CANDIDO Ana Paula C; CAPANZANA Mario V; ČAPKOVÁ Naděžda; CAPUANO Eduardo; CAPUANO Rocco; CAPUANO Vincenzo; CARDOSO Viviane C; CARLSSON Axel C; CASANUEVA Felipe F; CENSI Laura; CERVANTES-LOAIZA Marvin; CHAMNAN Parinya; CHAMUKUTTAN Snehalatha; CHAN Queenie; CHARCHAR Fadi J; CHATURVEDI Nish; CHEN Huashuai; CHERAGHIAN Bahman; CHIRLAQUE Maria-Dolores; CHUDEK Jerzy; CIFKOVA Renata; CIRILLO Massimo; CLAESSENS Frank; COHEN Emmanuel; CONCIN Hans; COOPER Cyrus; COSTANZO Simona; COWELL Chris; CRUJEIRAS Ana B; CRUZ Juan J; CUREAU Felipe V; CUSCHIERI Sarah; ARRIGO Graziella; ORSI Eleonora; DALLONGEVILLE Jean; DAMASCENO Albertino; DASTGIRI Saeed; DE CURTIS Amalia; DE GAETANO Giovanni; DE HENAUW Stefaan; DEEPA Mohan; DEGENNARO Vincent Jr; DEMAREST Stefaan; DENNISON Elaine; DESCHAMPS Valerie; DHIMAL Meghnath; DIKA Zivka; DJALALINIA Shirin; DONFRANCESCO Chiara; DONG Guanghui; DOROBANTU Maria; DORR Marcus; DRAGANO Nico; DRYGAS Wojciech; DU Yong; DUANTE Charmaine A; DUBOZ Priscilla; DUSHPANOVA Anar; DZIANKOWSKA-ZABORSZCZYK Elzbieta; EBRAHIMI Narges; EDDIE Ricky; EFTEKHAR Ebrahim; EFTHYMIOU Vasiliki; EGBAGBE Eruke E; EGHTESAD Sareh; EL-KHATEEB Mohammad; EL ATI Jalila; ELDEMIRE-SHEARER Denise; ELOSUA Roberto; ENANG Ofem; ERASMUS Rajiv T; ERBEL Raimund; EREM Cihangir; ERGOR Gul; ERIKSEN Louise; ERIKSSON Johan G; ESMAEILI Ali; EVANS Roger G; FAKHRADIYEV Ildar; FALL Caroline H; FARAMARZI Elnaz; FARJAM Mojtaba; FARZI Yosef; FATTAHI Mohammad Reza; FAWWAD Asher; FELIX-REDONDO Francisco J; FERGUSON Trevor S; FERNANDEZ-BERGES Daniel; FERRARI Marika; FERRECCIO Catterina; FERREIRA Haroldo S; FERRER Eldridge; FESKENS Edith J M; FLOOD David; FORSNER Maria; FOSSE Sandrine; FOTTRELL Edward F; FOUAD Heba M; FRANCIS Damian K; FRONTERA Guillermo; FURUSAWA Takuro; GACIONG Zbigniew; GARNETT Sarah P; GASULL Magda; GAZZINELLI Andrea; GEHRING Ulrike; GHADERI Ebrahim; GHAMARI Seyyed-Hadi; GHANBARI Ali; GHASEMI Erfan; GHEORGHE-FRONEA Oana-Florentina; GHIMIRE Anup; GIALLUISI Alessandro; GIAMPAOLI Simona; GIANFAGNA Francesco; GILL Tiffany K; GIRONELLA Glen; GIWERCMAN Aleksander; GOLTZMAN David; GOMULA Aleksandra; GONCALVES Helen; GONCALVES Mauer; GONZALEZ-CHICA David A; GONZALEZ-GROSS Marcela; GONZALEZ-RIVAS Juan P; GONZALEZ-VILLALPANDO Maria-Elena; GONZALEZ Angel R; GOTTRAND Frederic; GRAFNETTER Dusan; GRODZICKI Tomasz; GRONTVED Anders; GUERRERO Ramiro; GUJRAL Unjali P; GUPTA Rajeev; GUTIERREZ Laura; GWEE Xinyi; HAGHSHENAS Rosa; HAKIMI Hamid; HAMBLETON Ian R; HAMZEH Behrooz; HANEKOM Willem A; HANGE Dominique; HANTUNEN Sari; HAO Jie; KUMAR Rachakulla Hari; HAROONI Javad; HASHEMI-SHAHRI Seyed Mohammad; HATA Jun; HEIDEMANN Christin; HENRIQUE Rafael dos Santos; HERRALA Sauli; HERZIG Karl-Heinz; HESHMAT Ramin; HO Sai Yin; HOLDSWORTH Michelle; HOMAYOUNFAR Reza; HOPMAN Wilma M; HORIMOTO Andrea R V R; HORMIGA Claudia; HORTA Bernardo L; HOUTI Leila; HOWITT Christina; HTAY Thein Thein; HTET Aung Soe; HTIKE Maung Maung Than; HUERTA Jose Maria; HUHTANIEMI Ilpo Tapani; HUISMAN Martijn; HUSSEINI Abdullatif; HUYBRECHTS Inge; IACOVIELLO Licia; IAKUPOVA Ellina M; IANNONE Anna G; WONG Norazizah Ibrahim; IJOMA Chinwuba; IRAZOLA Vilma E; ISHIDA Takafumi; ISIGUZO Godsent C; ISLAM Sheikh Mohammed Shariful; ISLEK Duygu; ITTERMANN Till; IWASAKI Masanori; JAASKELAINEN Tuija; JACOBS Jeremy M; JADDOU Hashem Y; JADOUL Michel; JALLOW Bakary; JAMES Kenneth; JAMIL Kazi M; JANUS Edward; JARVELIN Marjo-Riitta; JASIENSKA Grazyna; JELAKOVIC Ana; JELAKOVIC Bojan; JENNINGS Garry; JHA Anjani Kumar; JIMENEZ Ramon O; JOCKEL Karl-Heinz; JOKELAINEN Jari J; JONAS Jost B; JOSHI Pradeep; JOSIPOVIC Josipa; JOUKAR Farahnaz; JOZWIAK Jacek; KAFATOS Anthony; KAJANTIE Eero O; KALMATAYEVA Zhanna; KARKI Khem B; KATIBEH Marzieh; KAUHANEN Jussi; KAZAKBAEVA Gyulli M; KAZE Francois F; KE Calvin; KEINANEN-KIUKAANNIEMI Sirkka; KELISHADI Roya; KERAMATI Maryam; KERSTING Mathilde; KHADER Yousef Saleh; KHALEDIFAR Arsalan; KHALILI Davood; KHEIRI Bahareh; KHERADMAND Motahareh; KHOSRAVI Alireza; KIECHL-KOHLENDORFER Ursula; KIECHL Sophia J; KIECHL Stefan; KINGSTON Andrew; KLAKK Heidi; KLÁNOVÁ Jana; KNOFLACH Michael; KOLSTEREN Patrick; KONIG Jurgen; KORPELAINEN Raija; KORROVITS Paul; KOS Jelena; KOSKINEN Seppo; KOWLESSUR Sudhir; KOZIEL Slawomir; KRIEMLER Susi; KRISTENSEN Peter Lund; KROMHOUT Daan; KUBINOVA Ruzena; KUJALA Urho M; KULIMBET Mukhtar; KURJATA Pawel; KYOBUTUNGI Catherine; LA Quang Ngoc; LABADARIOS Demetre; LACHAT Carl; LAID Youcef; LALL Lachmie; LANKILA Tiina; LANSKA Vera; LAPPAS Georg; LARIJANI Bagher; LATT Tint Swe; LAURENZI Martino; LEHMANN Nils; LEHTIMAKI Terho; LEMOGOUM Daniel; LEUNG Gabriel M; LI Yanping; LIMA-COSTA M Fernanda; LIN Hsien-Ho; LIND Lars; LISSNER Lauren; LIU Xiaotian; LOPEZ-GARCIA Esther; LOPEZ Tania; LOZANO Jose Eugenio; LUKSIENE Dalia; LUNDQVIST Annamari; LUNET Nuno; LUSTIGOVA Michala; MACHADO-COELHO George L L; MACHADO-RODRIGUES Aristides M; MACIA Enguerran; MACIEIRA Luisa M; MADAR Ahmed A; MAESTRE Gladys E; MAGGI Stefania; MAGLIANO Dianna J; MAGRIPLIS Emmanuella; MAHASAMPATH Gowri; MAIRE Bernard; MAKDISSE Marcia; MALEKPOUR Mohammad-Reza; MALEKZADEH Fatemeh; MALEKZADEH Reza; RAO Kodavanti Mallikharjuna; MALYUTINA Sofia; MANIEGO Lynell V; MANIOS Yannis; MANNIX Masimango Imani; MANSOUR-GHANAEI Fariborz; MANZATO Enzo; MARGOZZINI Paula; MARINO Joany; MARQUES Larissa Pruner; MARTORELL Reynaldo; MASCARENHAS Luis P; MASINAEI Masoud; MATHIESEN Ellisiv B; MATSHA Tandi E; POSSO Anselmo J. 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M.; VAN ZUTPHEN Elisabeth M.; VANDERSCHUEREN Dirk; VANUZZO Diego; VASAN Senthil K; VEGA Tomas; VELASQUEZ-MELENDEZ Gustavo; VERSTRAETEN Roosmarijn; VIET Lucie; VILLALPANDO Salvador; VIOQUE Jesus; VIRTANEN Jyrki K; VISWANATHAN Bharathi; VOUTILAINEN Ari; BEBAKAR Wan Mohamad Wan; MOHAMUD Wan Nazaimoon Wan; WANG Chongjian; WANG Ningli; WANG Qian; WANG Ya Xing; WANG Ying-Wei; WANNAMETHEE S Goya; WEBSTER-KERR Karen; WEDDERKOPP Niels; WEI Wenbin; WESTBURY Leo D; WHINCUP Peter H; WIDHALM Kurt; WIDYAHENING Indah S; WIECEK Andrzej; WILKS Rainford J; WILLEIT Johann; WILLEIT Peter; WILSGAARD Tom; WOJTYNIAK Bogdan; WONG Andrew; WONG Emily B; WOODWARD Mark; WU Frederick C; XU Haiquan; XU Liang; YAACOB Nor Azwany; YAN Li; YAN Weili; YOOSEFI Moein; YOSHIHARA Akihiro; YOUNGER-COLEMAN Novie O; YU Yu-Ling; YU Yunjiang; YUSOFF Ahmad Faudzi; ZAINUDDIN Ahmad A; ZAMANI Farhad; ZAMBON Sabina; ZAMPELAS Antonis; ZAW Ko Ko; VRKIC Tajana Zeljkovic; ZENG Yi; ZHANG Zhen-Yu; ZHOLDIN Bekbolat; ZIMMET Paul; ZITT Emanuel; ZOGHLAMI Nada; CISNEROS Julio Zuniga; EZZATI Majid
• Year of publication: 2023
• Type: Article in Periodical
• Magazine / Source: Nature Medicine
• MU Faculty or unit: Faculty of Science
• web: https://www.nature.com/articles/s41591-023-02610-2
• Doi: http://dx.doi.org/10.1038/s41591-023-02610-2
• Keywords: BETA-CELL DYSFUNCTION; PLASMA-GLUCOSE; GLYCATED HEMOGLOBIN; BLOOD-GLUCOSE; INSULIN-RESISTANCE; UNITED-STATES; HBA(1C); HBA1C; RISK; CLASSIFICATION
• Description: Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance.