Potent synergistic effects of dulaglutide and food restriction in prevention of olanzapine-induced metabolic adverse effects in a rodent model

• Authors: HORSKÁ Kateřina; KUČERA Jan; DRAŽANOVÁ Eva; KUZMÍNOVÁ Gabriela; AMCHOVÁ Petra; HRICKOVÁ Mária; RUDÁ Jana; SKREDE Silje
• Year of publication: 2024
• Type: Article in Periodical
• Magazine / Source: Biomedicine and Pharmacotherapy
• MU Faculty or unit: Faculty of Medicine
• Web: https://www.sciencedirect.com/science/article/pii/S0753332224006474
• Doi: http://dx.doi.org/10.1016/j.biopha.2024.116763
• Keywords: Antipsychotic; Olanzapine; metabolic adverse effects; GLP-1 receptor agonist; Schizophrenia
• Description: A combined strategy of dulaglutide and food restriction manifested a massive synergistic benefit. GLP-1RAs represent a promising strategy and deserve thorough future research. Our findings underline the potential importance of lifestyle intervention in addition to GLP-1 RA treatment.

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