Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats

• Authors: FRESCURA Francesca; ŠTARK Tibor; TIZIANI Edoardo; DI MARTINO Serena; RUDÁ Jana; DRAGO Filippo; FERRARO Luca; MICALE Vincenzo; BEGGIATO Sarah
• Year of publication: 2024
• Type: Article in Periodical
• Magazine / Source: PHARMACOLOGICAL REPORTS
• MU Faculty or unit: Faculty of Medicine
• Web: https://link.springer.com/article/10.1007/s43440-024-00604-6
• Doi: http://dx.doi.org/10.1007/s43440-024-00604-6
• Keywords: AM251;Novel object recognition test;Kynurenine Pathway;Haloperidol;Peripubertal treatment;Schizophrenia
• Description: The present findings suggest that the cognitive deficit observed in MAM rats may be related to enhanced PFC KYNA levels which could be, in turn, mediated by the activation of cannabinoid CB1 receptor. These results further support the modulation of brain KYNA levels as a potential therapeutic strategy to ameliorate the cognitive dysfunctions in schizophrenia.

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