Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey

• Authors: LAHMER Tobias; SALMANTON-GARCIA Jon; MARCHESI Francesco; EL-ASHWAH Shaimaa; NUCCI Marcio; BESSON Caroline; ITRI Federico; JAKSIC Ozren; COLOVIC Natasha; WEINBERGEROVÁ Barbora; SEVAL Guldane Cengiz; ADZIC-VUKICEVIC Tatjana; SZOTKOWSKI Tomas; SILI Uluhan; DARGENIO Michelina; JENS van Praet; JAAP van Doesum; SCHOENLEIN Martin; RACIL Zdenek; ZAK Pavel; POULSEN Christian Bjorn; MAGLIANO Gabriele; JIMENEZ Moraima; BONUOMO Valentina; PIUKOVICS Klara; DRAGONETTI Giulia; DEMIRKAN Fatih; BLENNOW Ola; VALKOVIC Toni; GOMES Da Silva Maria; MAERTENS Johan; GLENTHOJ Andreas; FERNANDEZ Noemi; BERGANTIM Rui; VERGA Luisa; PETZER Verena; OMRANI Ali S; MENDEZ Gustavo-Adolfo; MACHADO Marina; LEDOUX Marie-Pierre; BAILEN Rebeca; DUARTE Rafael F; ILARIA Del Principe Maria; FARINA Francesca; MARTIN-PEREZ Sonia; DAVILA-VALLS Julio; MARCHETTI Monia; BILGIN Yavuz M; FRACCHIOLLA Nicola S; CATTANEO Chiara; ESPIGADO Ildefonso; CORDOBA Raul; COLLINS Graham P; LABRADOR Jorge; FALCES-ROMERO Iker; PREZIOSO Lucia; MEERS Stef; PASSAMONTI Francesco; BUQUICCHIO Caterina; LOPEZ-GARCIA Alberto; KULASEKARARAJ Austin; ORMAZABAL-VELEZ Irati; CUCCARO Annarosa; GARCIA-VIDAL Carolina; BUSCA Alessandro; NAVRATIL Milan; NICK de Jonge; BIERNAT Monika M; GUIDETTI Anna; ABU-ZEINAH Ghaith; SAMARKOS Michail; ANASTASOPOULOU Amalia; CRISTINA de Ramon; GONZALEZ-LOPEZ Tomas Jose; HOENIGL Martin; FINIZIO Olimpia; PINCZES Laszlo Imre; ALI Natasha; VENA Antonio; TASCINI Carlo; STOJANOSKI Zlate; MERELLI Maria; EMARAH Ziad; KOHN Milena; BARAC Aleksandra; MLADENOVIC Milos; MISKOVIC Bojana; ILHAN Osman; COLAK Gokce Melis; CERNAN Martin; GRAEFE Stefanie K; AMMATUNA Emanuele; HANAKOVA Michaela; VISEK Benjamin; CABIRTA Alba; NORDLANDER Anna; RODRIGUES Raquel Nunes; HERSBY Ditte Stampe; ZAMBROTTA Giovanni Paolo Maria; WOLF Dominik; NUNEZ-MARTIN-BUITRAGO Lucia; ARELLANO Elena; TOMMASO Francesco Aiello; GARCIA-SANZ Ramon; PRATTES Juergen; EGGER Matthias; LIMONGELLI Alessandro; BAVASTRO Martina; CVETANOSKI Milche; DIBOS Miriam; RASCH Sebastian; RAHIMLI Laman; CORNELY Oliver A; PAGANO Livio
• Year of publication: 2024
• Type: Article in Periodical
• Magazine / Source: Infection
• MU Faculty or unit: Faculty of Medicine
• Web: https://link.springer.com/article/10.1007/s15010-023-02169-7
• Doi: http://dx.doi.org/10.1007/s15010-023-02169-7
• Keywords: COVID-19; haematological malignancies
• Description: The risk for a severe coronavirus disease 2019 (COVID-19) with need for an intensive care unit (ICU) admission in a non-immunocompromised vaccinated population dropped from 5% at the beginning of the pandemic to at least 0.2% and is still decreasing since the omicron strain dominates the COVID-19 pandemic [1]. Beyond the risk factors identified for a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection like male sex, older age, and comorbidities such as cardiovascular disease, lung disease or obesity, patients with a history of malignancy, specifically patients with haematological malignancy, are prone to develop a complicated SARS-CoV-2 infection with need for ICU which is still associated with poorer clinical outcome. The circumstances of a widely heterogenous population with regards to the type of haematological malignancy, extent of disease, haematological malignancy treatment history, and baseline performance status are even more challenging in the environment of an ICU. Although, data referring to critically ill COVID-19 patients regarding treatment strategies and outcome are widely available, data referring to critically ill patients with haematological malignancy are scarce and underreported. The aim of this study is to analyze the epidemiology, risk factors and outcome of patients with haematological malignancy with need for an ICU setting using the data from the large-scale EPICOVIDEHA registry of the European Hematology Association—Scientific Working Group Infectious in Hematology (EHA-SWG).