Publication details
ZKUŠENOST S PODÁNÍM KLOZAPINU A DLOUHODOBĚ PŮSOBÍCÍHO PALIPERIDONU PALMITÁTU V KOMBINACI U PACIENTA S PARANOIDNÍ SCHIZOFRENIÍ A ABÚZEM MARIHUANY
| Title in English | EXPERIENCE WITH THE ADMINISTRATION OF CLOZAPINE AND LONG-ACTING PALIPERIDONE PALMITATE IN COMBINATION IN A PATIENT WITH PARANOID SCHIZOPHRENIA AND MARIJUANA ABUSE |
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| Authors | |
| Year of publication | 2024 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.cspsychiatr.cz/detail.php?stat=1584 |
| Keywords | clozapine, long-acting injectable antipsychotics, marijuana abuse, nonadherence, paliperidone palmitate, schizophrenia, substance use disorder |
| Description | Addictive disorders are a very common comorbidity of schizophrenia, which increases the severity of symptoms, worsens the course of the disease, and is also associated with high nonadherence to therapy. Of the possible therapeutic interventions, according to the available findings, clozapine appears to be the more effective drug. Due to the frequent non-adherence to therapy, the interest of the professional public is also directed towards long-acting injectable forms of antipsychotics, the administration of which is not yet standard for this dual diagnosis. We present a case report of a pharma-coresistant patient with paranoid schizophrenia and co-occurring substance use disorder with predominant marijuana abuse, in whom a positive clinical effect was recorded when the combination of clozapine and the long-acting antipsychotic paliperidone palmitate was administered. We were based on the patient´s medication history. |